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KMID : 0648320090150010042
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Journal of The Korean Society of Hypertension
2009 Volume.15 No. 1 p.42 ~ p.50
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Effects of Angiotensin II Receptor Blocker on Endothelial Progenitor Cells in Spontaneously Hypertensive Rats
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Choi Sung-Hyun
Park Eun-Hye
Sim Cho-Eun
Baek Sang-Hong
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Abstract
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Background: Reactive oxygen species (ROS) generation is one of the main mechanisms involved in angiotensin II (Ang II)-induced tissue damage. Endothelial progenitor cells (EPCs) may play a critical role of vasoregeneration and vasorepair in cardiovascular disease. Angiotensin receptor blocker (ARB) has a blood pressure lowering effect and a down regulation of oxidative stress. We investigated the effects of the ARB, telmisartan, on the EPCs function and on the regulation of ROS in spontaneously hypertensive rats (SHR).
Material and Methods: Eight-week-old SHR were divided into following three groups; SHR control group, tricholorothiazide treated group (TCTZ 1.6mg/kg/day),and telmisartan treated group (TERT 5mg/kg/day). Wistar-Kyoto (WKY) rats were used as hypertension control group. After 14days of drug treatment, blood pressure were measured by tail_cuff method. Bone marrow mononuclear cells were isolated and cultured to assay EPCs colony formation. Oxidative stress of cardiac and aortic tissues were evaluated by DHE stain and malondialdehyde (MDA) of lipid peroxidation by TBARS assay.
Results: TCTZ or TERT treatment significantly decreased blood pressure in SHR. Increased aortic wall thickness was more significantly reduced in TERT group rather than TCTZ group. The oxidative stress and lipid peroxidation of cardiac and aortic tissue were significantly decreased in TERT group than TCTZ group. TERT and TCTZ had similar degree improvement of EPC colony formation in hypertension.
Conclusion: These results show that telmisartan, an ARB, has a cardiovascular protection effect through blood pressure lowering effect, antioxidative mechanism and improvement of EPC dysfunction in hypertension.
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KEYWORD
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Spontaneous hypertensive rat, Angiotensin II, EPC, ARB
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